PSA Coding variants: Functional analysis, multiethnic association and risk models for prostate cancer

This study will create new knowledge by critically evaluating 2 promising KLK3 (PSA) SNP biomarkers, at both the molecular functional and diagnostic level, with a view to their incorporation in a risk model that will improve the existing PSA test and allow the detection of prostate cancer at an earlier stage and/or selectively identify prostate cancers that should be treated from those that grow slowly and would not surface or cause significant symptoms during the lifetime of the patients in multiethnic populations. The outcomes from this study therefore may have the potential to save or improve lives when used to screen/test men for prostate cancer and guide decisions about treatment.

The objective of this project is to elucidate the functional significance of these newly discovered SNPs in prostate cancer aetiology, and systematically investigate the association of non-synonymous KLK3 SNPs with prostate cancer predisposition and prognosis.


Judith Clements APCRC-Q, IHBI, QUT, TRI
Jyotsna Batra APCRC-Q, IHBI, QUT, TRI
Ashley Buckle Monash University
Hans Lilja Memorial Sloane Kettering Cancer Centre

Associate Investigators

Amanda Spurdle QIMR Berghofer
Oded Kleifeld Monash University
Hannu Koistinen University of Helsinki
Rosalind A Eeles Institute of Cancer Research, UK
Vedang Murthy Tata Memorial Centre, India
Sunita Saxena Institute of Pathology-ICMR, Safdarjang Hospital, India
Vanessa Hayes Garvan Institute of Medical Research
Jeffrey Gorman Protein Discovery Centre at Queensland Institute of Medical Research
Rodney Webb York University, Toronto
Ulf-Hakan Stenman University of Helsinki


2015 - 2016