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About Us

Judith Clements AC

Judith Clements AC

Positions

  • Scientific Director, APCRC-Q
  • Distinguished Professor and Head, Kallikrein Protease & Tumour Microenvironment Group, IHBI, QUT
  • Adjunct Professor, School of Medicine, University of Queensland
  • NHMRC Principal Research Fellow

Contact Details

Phone
+61 7 3443 7241

Qualifications

  • PhD (Endocrinology) Monash University, Department of Medicine, 1989
  • Master of Applied Science, Royal Melbourne Institute of Technology, Melbourne, 1983
  • Bachelor of Applied Science (High Distinction), Royal Melbourne Institute of Technology, Melbourne, 1982
  • Diploma of Laboratory Technology, Royal Melbourne Institute of Technology, Melbourne, 1969

Biography

Distinguished Professor Clements has over 30 years of experience as a molecular and cell biologist in the endocrine field with expertise in neuroendocrine functional peptides and proteases – particularly the kallikrein-like serine protease family - in hormone dependent cancers, with a major emphasis on prostate cancer. She has published over 190 articles in refereed international journals and book chapters and has an H-index of 45 with >7000 career citations (Google Scholar).

Her research covers the spectrum of biochemistry, cellular and molecular biology, using both in vitro and in vivo cell models, and includes proteomic, transcriptomic and genetic studies and the development and use of 3-dimensional cell culture systems better mimicking the tumour microenvironment. Her work encompasses understanding the regulation of endocrine/paracrine and autocrine mechanisms underpinning prostate cancer maintenance and progression and the identification of potential new diagnostic, prognostic and therapeutic targets. She is internationally recognised as an expert in her field and has been awarded the Silver and Gold medals of the international Frey-Werle Foundation for her work. She leads the Queensland node of the international PRACTICAL consortium, has led the Australian Prostate Cancer BioResource (tissue bank) for more than 10 years and is Chair of the Queensland Board of the PCFA.

Awards and grants

Awards

2015 Companion of the Order of Australia
2013-2017 Elected to the Council of the International Proteolysis Society
2012 Women in Technology (WiT) Biotech Outstanding Achievement Award
2011 Queensland University of Technology Vice Chancellor’s Award for Research Excellence
2007 Gold Medal, E.K.Frey–E.Werle Foundation for pioneering work in the Kallikrein field
2006 Research featured in “Ten Of The Best” National Health and Medical Research Council funded health and medical research successes
2005 Alban Gee Prize, Urological Society of Australasia Annual Scientific Meeting
2001 Queensland University of Technology Faculty of Science Distinguished Award for Excellence in Research
2000 National Health and Medical Research Council Principal Research Fellowship
2000 Silver Medal and Honorary Membership of the E.K.Frey–E.Werle Foundation (awarded at the International Conference, Kinin 2000, Munich)
1998 Alban Gee Prize, Urological Society of Australasia Annual Scientific Meeting
1995 National Health and Medical Research Council Senior Research Fellowship
1991 Prize for an “Outstanding Presentation”, Kinin 91, International Conference on Kallikreins and Kinins, Munich, Germany

    Grants

    2016-2017

    The Cancer Council Queensland

    Targeting kallikrein proteases to improve treatment options for ovarian cancer Clements
    2016 Prostate Cancer Foundation of Australia KLK14 as a novel therapeutic target in muscle wasting induced by androgen deprivation therapy Clements
    2015-2016 The Cancer Council Queensland PSA coding variants: functional analysis, multiethnic association and risk models for prostate cancer Clements
    2014-2017 PCFA/Movember Foundation Movember Revolutionary Team Award Nelson, Clements, et al
    2014-2017 PCFA/Movember Foundation Australian Prostate Cancer Clinical Registry –Queensland Node Nelson, Clements, et al
    2014-2016 National Health & Medical Research Council of Australia Disruption of proteolytic cascades in the skin: towards halting the atopic march
    2014-2015 The Cancer Council Queensland  KLK4 is a key regulator of the reactive stromal microenvironment in prostate cancer
    2014-2015 Cancer Australia miSNPs as novel diagnostic and prognostic biomarkers for prostate cancer
    2013-2017 Australian Government Department of Health Australian Prostate Cancer Research Centre – Queensland Nelson, Clements
    2013-2015

    National Health & Medical Research Council of Australia

    Identification and characterisation of a novel genetic signature at the 5p15 region associated with risk of prostate cancer

    2012-2014 Australia-India Strategic Research Found (AISRF) Molecular pathways regulating ovarian cancer cell plasticity and stem cell properties Clements, Dong, Batra and Bapat
    2012-2014 National Health and Medical Research Council (NHMRC) The role of angiopoietin-1 in the self renewal and metastasis of prostate cancer stem cells. Ling, Clements, Nelson
    2012-2013 Queensland Cancer Fund/ The Cancer Council Queensland Kallikrein proteases are key players in the ovarian tumour-stroma microenvironment Clements, Kleifeld, Loessner, Harris, Magdolen
    2011-2016 NHMRC Principal Research Fellowship: Defining the role of the PSA-related Kallikrein serine proteases in hormone dependent cancer progression Clements
    2011-2014 ARC Discovery Development and validation of virtual epithelial cancer models using an integrated modelling and experimental three-dimensional approach. Hutmacher, McElwain, Russell, Flegg, Loessner, Clements, Dalton, Byrne
    2011-2013 Cancer Australia/ Prostate Cancer Foundation of Australia PSA as a therapeutic target: an integrated systems biology approach to discover the pathways initiated by PSA activity in prostate cancer progression Clements, Overall, Gorman, Hutmacher, Nelson
    2011-2013 NHMRC KLK4 is a master regulator of tumour microenvironment remodelling in prostate cancer and bone metastasis. Clements, Nelson, Hutmacher, Russell, Overall, Gorman, Harris
    2011-2013 Cancer Australia/ Prostate Cancer Foundation of Australia Targeted delivery of prostate cancer antigens to dendritic cells for immunotherapy Radford, Lahoud, Clements
    2011-2013 NHMRC In-depth association and functional studies assessing the role of novel single nucleotide polymorphisms in PSA and other kallikrein genes in prostate cancer Clements, Batra, Spurdle
    2010-2014 Cancer Australia/ Prostate Cancer Foundation of Australia Australian Prostate Cancer Bio-Resource Clements, Risbridger, Tilley, Sutherland et al
    2010-2014 NHMRC Enabling Grant for Australian Prostate Cancer Bio-Resource Clements, Risbridger, Tilley, Sutherland et al
    2010-2012 Queensland Smart State Smart State PhD Scholarship – Fuhrman-Luck,  Defining the kallikrein-related peptidase 4 protease degradome in prostate cancer Fuhrman-Luck & Clements
    2010-2012 Wesley Research Institute Kallikrein enzymes in ovarian cancer chemo-treatment Nicklin, Dong, Clements, Obermair
    2009-2013 Wesley Research Institute Collaborative Oncological Gene-environment Study (EU-COGS) CI: Giles, Assoc-I: Clements, English, Hayes, Hopper, Kedda, Nelson, Pedersen, Severi, Southey, Spurdle
    2009-2013 Australian Federal Government Establishment of a National Prostate Cancer Research Centre – Queensland Nelson, Clements
    2009-2015 National & International Research Alliances Program  Australian-Canadian Prostate Cancer Research Alliance Nelson, Gleave, Clements

    Research interests

    • Functional role of PSA and the related Kallikrein proteases in prostate and ovarian cancer
    • Role of variant Kallikrein isoforms in cancer
    • Role of Kallikrein proteases in bone metastasis
    • Predictive and prognostic biomarker potential of Kallikrein proteases
    • Functional role of genetic variation in the Kallikrein locus
    • Tumor-microenvironment influences in prostate and ovarian cancer
    • Bioengineered three dimensional in vitro and in vivo models of prostate and ovarian cancer progression.

    Current research projects

    • KLK4 is a master regulator of tumour microenvironment remodelling in prostate cancer and bone metastasis. (Clements, Nelson, Hutmacher, Russell, Overall, Gorman, Harris).
    • In-depth association and functional studies assessing the role of novel single nucleotide polymorphisms in PSA and other kallikrein genes in prostate cancer (Clements, Batra, Spurdle).
    • Development and validation of virtual epithelial cancer models using an integrated modelling and experimental three-dimensional approach. (Hutmacher, McElwain, Russell, Flegg, Loessner, Clements, Dalton, Byrne).
    • Kallikrein proteases are key players in the ovarian tumour-stroma microenvironment (Clements, Kleifeld, Loessner, Harris, Magdolen).
    • PSA as a therapeutic target: an integrated systems biology approach to discover the pathways initiated by PSA activity in prostate cancer progression (Clements, Overall, Gorman, Hutmacher, Nelson).
    • Molecular pathways regulating ovarian cancer cell plasticity and stem cell properties (Clements, Dong, Batra and Bapat).
    • Kallikrein enzymes in ovarian cancer chemo-treatment (Nicklin, Dong, Clements, Obermair).

    Top publications

    From a career total of 170

    • Clements JA, Fuller PJ, Mc Nally M, Nikolaidis I and Funder JW.  Estrogen regulation of kallikrein gene expression in the rat anterior pituitary.  Endocrinology 119: 268–273, 1986.
    • Clements JA, Matheson BA, Wines DR, Brady JM, Mac Donald RJ and Funder JW.  Androgen dependence of specific kallikrein gene family members expressed in rat prostate.  J. Biol. Chem. 263: 16132–16137, 1988.
    • Fuller PJ, Matheson BA, Verity K and Clements JA. Kallikrein gene expression in estrogen–induced pituitary tumors.  Mol. Cell. Endocrinol. 60: 225–232, 1988.
    • Clements JA. The glandular kallikrein family of enzymes: tissue–specific expression and hormonal regulation.  Endocrine Reviews, 10: 393–419, 1989.
    • Clements JA, Matheson BA and Funder JW.  Tissue–specific developmental expression of the kallikrein gene family in the rat.  J. Biol. Chem. 265: 1077–1081, 1990.
    More publications are available on PubMed

    Team

    • Dr Karen Chambers, Senior Research Assistant
    • Dr Ying Dong, Research Fellow
    • Miss Ruth Fuhrman-Luck, PhD Student
    • Dr Daniela Loessner, Postdoctoral Fellow
    • Miss Munasinghage Silva, PhD Student
    • Srilakshmi Srinavasan, Research Assistant
    • Dr Shane Stegeman, Postdoctoral Research Fellow
    • Mr Carson Stephens, Research Assistant
    • Tracy O'Mara
    • Grace Eng
    • Dr Trina Yeadon, National Project Manager

    Collaborators

    • Dr Viktor Magdalen, KliFlo der Frauenklinik, Munich, Germany
    • Dr David Kaplan, Tufts University, Boston, USA
    • Drs Stephen Chanock & Laufey Amundattoir, NCI/NIH, Bethesda, Maryland, USA
    • Dr Matthias Lutholf, Ecole de Polytechnic, Lausanne, Switzerland
    • Prof Ros Eeles, University College, London, UK
    • Prof Chris Overall, UBC, Vancouver, Canada
    • Prof Wayne Tilley, Hanson Cancer Centre, Adelaide
    • Prof Gail Risbridger, Monash University, Melbourne
    • Dr Oded Kleifeld, Monash University, Melbourne
    • Dr Amanda Spurdle, QIMR, Brisbane
    • Drs Peter Parsons & Glen Boyle, QIMR, Brisbane
    • Drs Jim Nicklin & Andreas Obermair, Wesley and Royal Brisbane & Women's Hospitals, Brisbane
    • Dr H Samarantunga, Aquesta Pathology, brisbane
    • Dr Jon Harris, IHBI, QUT, Brisbane
    • Dr Mike Doran, IHBI, QUT, Brisbane
    • A/Prof John Hooper, MMRI

    Professional memberships and associations

    Memberships

    2012- Program Organising Committee for TEMTIA-VII 2015
    2012- Member, Prostate Cancer Foundation of Australia National Board
    2012- Member, National Health and Medical Research Council Prostate Specific Antigen Testing Expert Advisory Committee
    2012- Member of the Translational Research Institute Academic Caucus
    2011- Australasian Regional Advisor (With Prof Mark Frydenberg, Victoria) for the Movember Global Action Plan Global Biomarker Initiative
    2010- Member of the International Society for Biological and Environmental Repositories (ISBER) Biospecimen Working Group
    2009- Elected Academic staff member of Queensland University of Technology Council
    2009- Chair, Appointments and Promotions Committee, Queensland Institute of Medical Research
    2009- Queensland Rhodes Scholarship Selection Committee (Deputy Chair 2012)
    2009- Member of the National Health and Medical Research Council Academy
    2008- Co-team leader of the Brisbane node of the PRACTICAL Prostate Cancer Genome-Wide Association Studies Consortium
    2008- Prostate Cancer Foundation of Australia Queensland Board (Chair 2012 - )
    2004- Editorial Board, Clinical Biochemistry
    2002- Member of Queensland Institute of Medical Research Council (National Health and Medical Research Council Representative 2002-2011)
    2001- Chair, Australian Prostate Cancer Bio-Resource Management Committee. Directing national co–ordination of the Australian Prostate Cancer Bio-Resource (tissue bank)

      Associations

      • American Association for Cancer Research
      • Australasian Biospecimen Network Association
      • Australia & New Zealand Urogenital & Prostate Cancer Clinical Trials Group
      • Australian Society for Biochemistry & Molecular Biology
      • Australian Society for Medical Research
      • Clinical Oncological Society of Australia
      • United States Endocrine Society
      • Endocrine Society of Australia
      • Human Proteome Organisation
      • International Proteolysis Society
      • International Society for Biological & Environmental Respositories
      • Metastasis Research Society
      • National Association of Research Fellows
      • Society for Basic Urologic Research
      • The Epithelio-Mesenchymal Transition (EMT) International Association
      • Urological Society of Australia & New Zealand
      • Women in Technology

      Upcoming Events

      Apr 13, 2019 - Apr 16, 2019 USANZ 2019
      Brisbane Convention and Exhibition Centre