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Translational Research

Presentations 2013

In 2013, APCRC-Q research fellows and students presented at the following national and international conferences:

Invited speaker and Session Chair (Advances in RNA-SEQ Data Analysis Session): Lehman M, Alternative Protein-Coding Transcripts in Prostate Cancer, Clinical Genomics and Informatics Europe Conference and Expo, Lisbon, Portugal, 3 – 5 December 2013.

Oral: Wagholikar A. A novel approach for improving chronic disease outcomes using intelligent personal health records in a collaborate care framework, Aritifical Intelligence in Health (AIH) Workshop, Dunedin, New Zealand, 3 December 2013.

Eight posters at IHBI Inspires Postgraduate Student Conference, Brisbane, 28 – 29 November 2013:

Poster: Sarkar P, Gunter J, Lubik A, Stylianou N, Hollier B, Pollak M, Nelson C. Insulin increases migration and invasion in androgen deprived prostate cancer cells.

Poster: Shah E, Stylianou N, Gunter J, Williams E, Nelson C, Hollier B. Repositioning "Old" Drugs for New Causes: Identifying New Treatments for Metastatic Prostate Cancer.

Poster: Srilakshmi S, Stephens C, Spurdle A, Clements J, Batra J. Functional validation of a KLK3 variant, rs17632542, with prostate cancer risk.

Poster: Stylianou N, Kashyap A, Jovanovic L, Lehman M, Wang C, Gunter J, Nelson C, Hollier B. Investigating the Epithelial to Mesenchymal Transition in prostate cancer invasion and metastasis.

Poster: Tang KD, Ling MT(P). Inactivation of ATM/ATR DNA damage checkpoint promotes androgen induced chromosomal instability in prostate epithelial cells.

Poster: Thomas P, Walpole C, Seim I, Jeffery P, Jovanovic L, Herington A, Nelson C, Whiteside E, Chopin L. The expression and function of GHSROS, a long non-coding RNA encoded by the opposite strand of the ghrelin receptor gene, in prostate cancer.

Poster: Fuhrman-Luck R, Hastie M, Stansfield S, Stoll T, Rockstroh A, Lehman M, Nelson C, Loessner D, Gorman J, Clements J. Kallikrein-related peptidase 4 initiates tumour-stroma cross-talk in prostate cancer.

Poster: Lisle J, Mertens-Walker I, Stephens C, Stansfield S, Herington A, Clements J, Stephenson S-A. Do proteases regulate EphB4 in prostate cancer?

Poster: Stylianou N, Kashyap A, Jovanovic L, Lehman M, Wang C, Gunter J, Nelson C, Hollier B. Investigating the role of the epithelial to mesenchymal plasticity in prostate cancer invasion and metastasis. 6th TEMTIA Meeting, Alicante, Spain, 13 – 16 November 2013.

Poster: Eckert A, Williams E, Holzapfel B, Henkel J, Kelly J, Mellor I, Steck R, Hutmacher D, Nelson C, Clements J. Challenges and opportunities in establishing biobanking from a Body Donor Program, Australasian Biospecimen Network Association Annual Meeting, Melbourne, 14 – 15 November 2013.

One oral presentation and a Session Chair at 8th General Meeting of International Proteolysis Society (IPS), Cape Town, South Africa, 20 – 24 October 2013:

Oral: Herington A, Kallikrein-4 proteolysis of the EphB4 receptor tyrosine kinase initiates novel paracrine and nuclear actions of EphB4 in prostate cancer cells.

Session Chair: Judith Clements, Cancer and Metastasis Session

Podium: Batra J, Srinivasan S, Lose F, Kote-Jarai Z, Easton D, Eeles RA, Spurdle A, Clements JA. Identification of Kallikrein genetic variants associated with prostate cancer susceptibility using the iCOGS custom genotyping array, 4th International Conference on Stem Cells and Cancer (ICSCC-2013): Proliferation, Differentiation and Apoptosis, Haffkine Institute, Parel, Mumbai, India, 19-22 October 2013.

Poster: Lai J, An J, Vasireddy R, Lehman M, Dinger M, Srinivasan S, Moya L, Batra J, Clements J, Nelson C. Identification of differential expression of variant prostate specific transcripts at the SLC45A3 prostate cancer locus using RNAseq, 2013 Australasian Genomic Technologies Association Conference, Gold Coast, 13 – 16 October 2013.

Invited speaker: Clements J, 4th Australia China Biomedical Research Conference, Hangzhou, China, 6 – 15 October 2013.

One invited speaker and two poster presentations at the International Symposium on Kallikreins and Kallikrein-Related Peptidases, Toronto, Canada, 28 September – 1 October 2013:

Invited speaker: Clements J Kallikrein related-peptidases regulate metastasis and chemoresistance in ovarian cancer.

Poster: Stegeman S, Lose F, Spurdle A, Clements, J, Batra J. A genetic variation affecting mirna binding to KLK3 is associated with the risk of prostate cancer.

Poster: Srinivasan S, Stephens C, Spurdle A, Clements J, Batra J. Functional validation of a KLK3 variant, rs17632542, associated with prostate cancer risk.

Poster: Liberio M, Rockstroh A, Vasireddy R, Quinn R, Davis R, Nelson C. Eusynstyelamide B: a novel topoisomerase II poison induces DNA damage and a G2 cell cycle arrest in LNCaP cells. European Cancer Congress, Amsterdam, The Netherlands, 27 September – 1 October 2013.

Poster: Lai J, An J, Nelson C, Kote-Jarai Z, Easton D, Amin A, Eeles RA on behalf of PRACTICAL, Batra J. Short tandem repeats: An understudied reservoir of genetic variation for prostate cancer susceptibility. The Annual Scientific Meeting of the ESA and the SRB, Sydney, 25 – 28 August 2013.

Six invited presentations and 28 poster presentations at the Prostate Cancer World Congress held in Melbourne, 6 - 8 August 2013 and the Australian-Canadian Prostate Cancer Research Alliance Symposium held in Port Douglas, 14 – 17 August 2013:

Invited speaker: Williams E, Impact of tumour cell plasticity on CTC capture.

Invited speaker: Batra J, Prostate cancer GWAS: fine-mapping to function.

Invited speaker: Stephenson S-A, ephB4 – an “eph”ective contributor to prostate cancer.

Invited speaker: Clements J, The KLK degradome and downstream signaling pathways in a prostate stromal microenvironment.

Invited speaker: Hollier B, Defining a role for EMT in prostate cancer metastasis.

Invited speaker: Holzapfel B, Establishment of a novel xenograft model to study the homing sequence of prostate cancer cells to engineered human bone.

Poster: An J, Lai J, Lehman M, Nelson C. MiRDeep*: An Integrated Application Tool For MiRNA Identification From RNA Sequencing Data.

Poster: Batra J, Srinivasan S, Lose F, Kote-Jarai Z, Easton D, Eeles R, PRACTICAL consortium, The Australian Prostate Cancer Bioresource, Spurdle A, Clements J. Association and functional analysis of Kallikrein genetic variants with prostate cancer.

Poster: Chambers K, Doran M, Russell P, Clements J, Culturing prostate cells as 3D micro-aggregates for drug testing.

Poster: Fuhrman-Luck R, Hastie M, Stansfield S, Stoll T, Rockstroh A, Lehman M, Nelson C, Loessner D, Gorman J, Clements J. Kallikrein-related peptidase 4 initiates tumour-stroma cross-talk in prostate cancer.

Poster: Futrega K, Chambers K, Lott B, Clements J, Russell P, Doran M. High-throughput 3D tissue culture for prostate cancer drug screening.

Poster: Futrega K, Chambers K, Clements J, Russell P, Doran M. Engineering a High-Throughput Prostate Cancer Stem Cell Niche Mimic.

Poster: Gunter J, Lubik A, Vasireddy R, Stylianou N, Hendy S, Hollier B, Gleave M, Pollak M, Herington A, Nelson C. Metformin modulates key insulin-induced survival pathways in prostate cancer cells.

Poster: Jeet V, Nelson C. YKL40 as a therapeutic target for the treatment of metastatic prostate cancer.

Poster: Jovanovic L, Mills M, Eckert A, Wood S, Lehman M, McCaffrey E, Oleinikova I, Nelson C, Use of the CellSearch® Platform in Enumeration and Profiling of Circulating Tumour Cells.

Poster: Lai J, An J, Nelson CC, Kote-Jarai Z, Easton D, Amin A, Eeles RA, on behalf of PRACTICAL consortium, Clements J, Batra J. Genome-wide analyses reveal specific functional repetitive DNA that are proximal to prostate cancer risk alleles.

Poster: Lehman ML, Wang C, Tevz G, An J, Lai J, Hendy S, McPherson S, Sadowksi M, Nelson CC. Identification of novel androgen and antiandrogen regulated long noncoding RNAs and protein-coding RNAs in prostate cancer.

Poster: Ling MT(P), Kwan PS. Daxx regulates mitotic progression and prostate cancer predisposition.

Poster: Lisle J, Mertens-Walker I, Stephens C, Stansfield S, Herington A, Clements J, Stephenson S-A. Do proteases regulate EphB4 in prostate cancer?

Poster: Lubik A, Vasireddy R, Gunter J, Ettinger S, Hendy S, Hill M, Gleave M, Pollak M, Herington A, Nelson C. Simvastatin suppresses insulin induced steroidogenesis and fatty acid synthesis in prostate cancer.

Poster: Nelson C, Lubik A, Gunter J, Lehman M, Soekmadji C, Wang C, Gleave M, Finn S, Pollak M, Herington A. Insulin stimulates fatty acid synthesis and metabolism in androgen deprived human prostate cancer cell lines.

Poster: Sadowksi M, Pouwer R, Lubik A, McPherson S, Nelson C. Evaluation of the fatty acid synthase inhibitor triclosan in prostate cancer cells.

Poster: Sarkar P, Gunter J, Lubik A, Stylianou N, Hollier B, Pollak M, Nelson C. Insulin increases migration and invasion in androgen deprived prostate cancer cells.

Poster: Soekmadji C, Russell PJ, Hill M, Dunne JC, Jordan TW, Nelson C. Androgen influence on prostate cancer exosomes production and content.

Poster: Srilakshmi S, Stephens C, Spurdle A, Clements J, Batra J. Functional validation of a KLK3 variant, rs17632542, with prostate cancer risk.

Poster: Stephenson S-A, Mertens-Walker I, Lisle J, Nyberg W, Stephens C, Burke L, Rutkowski R, Herington A. Nuclear localization of the receptor tyrosine kinase EphB4 in prostate cancer cells.

Poster: Stylianou N, Kashyap A, Jovanovic L, Lehman M, Wang C, Gunter J, Nelson C, Hollier B. Investigating the Epithelial to Mesenchymal Transition in prostate cancer invasion and metastasis.

Poster: Tang KD, Ling MT(P). Inactivation of ATM/ATR DNA damage checkpoint promotes androgen induced chromosomal instability in prostate epithelial cells.

Poster: Tevz G, Lehman M, Lai J, An J, Wang C, Hendy SC, Nelson CC. Androgen responsive non-coding RNA regulates the expression of prostate cancer associated CTBP1 in LNCaP.

Poster: Thomas P, Walpole C, Seim I, Jeffery P, Jovanovic L, Herington A, Nelson C, Whiteside E, Chopin L. The expression and function of GHSROS, a long non-coding RNA encoded by the opposite strand of the ghrelin receptor gene, in prostate cancer.

Poster: Tse B, Cowin G, Soekmadji C, Jovanovic L, Thierry B, Russell P. Application of PSMA-targeting magnetic nanoparticles into MRI of prostate cancer.

Poster: Vasireddy R, Cochrane D, Lubik A, Fazli L, Hollier B, Lehman M, Nelson C. Role of GADD45G in transcriptional regulation of androgen-responsive genes and prostate cancer cell survival.

Wagholikar A, Graves N, Nelson C. An evaluation framework for a wider adoption of self-managed interventions during management of advanced prostate cancer.

Wang C, Taciroglu A, Maetschke S, Nelson C, Ragan MA, Davis M. mCOPA: analysis of heterogeneous features in cancer expression data.

Two oral and nine poster presentations at the TRI Early Career Researcher Symposium, 19 July 2013, Brisbane:

Oral: Jeet V, Hollier B, Nelson C. Targeting YKL40 for the treatment of metastatic prostate cancer. (Awarded second prize for oral presentation).

Oral: Batra J, Srinivasan S, Lose F, Kote-Jarai Z, Easton D, Eeles R, PRACTICAL consortium, The Australian Prostate Cancer Bioresource, Spurdle A, Clements J. Association and functional analysis of kallikrein genetic variants with prostate cancer risk and metastasis. (Awarded third prize for poster presentation).

Poster: Tevz G, Lehman M, Jeet V, Lai J, An J, Wang C, Hendy S, Nelson C. CTBP1 – an androgen regulated multitasking genomic locus in prostate cancer. (Joint winner for people’s choice poster award).

Poster: Srinivasan S, Stephens C, Spurdle A, Clements J, Batra J. Functional validation of a KLK3 variant, RS17632542, with prostate cancer risk.

Poster: Tse B, Cowin G, Soekmadji C, Jovanovic L, Vasireddy R, Liu M, Thierry B, Russell P. Application of PSMA-targeting magnetic nanoparticles into MRI of prostate cancer. (Joint winner for people’s choice poster award).

Poster: Tang KD, Chiu Y-T, Wong Y-C, Ling MT(P). Inactivation of ATM/ATR DNA damage checkpoint promotes androgen induced chromosomal instability in prostate epithelial cells.

Poster: Vasireddy R, Cochrane D, Lubik A, Fazli L, Hollier B, Lehman M, Nelson C, GADD45G acts as master regulator in prostate cancer cell survival and progression.

Poster: Wang C, Taciroglu A, Maetschke S, Nelson C, Ragan M, Davis M. mCOPA: analysis of heterogeneous features in cancer expression data.

Poster: Moon H, Lee CS, Inder KL, Sharma S, Choi E, Black DM, Le Cao KA, Winterford C, Coward JI, Ling MT(P), the Australian Prostate Cancer Bioresource, Craik DJ, Parton RG, Russell PJ, Hill MM. Cavin-1 alters oncogenic effects of caveolin-1 microdomains in prostate cancer.

Poster: Stylianou N, Kashyap A, Jovanovic L, Lehman M, Wang C, Gunter J, Nelson C, Hollier B. Investigating the epithelial to mesenchymal transition in prostate cancer invasion and metastasis.

Poster: Soekmadji C, Nelson C, Russell PJ. Exosomes as biomarkers for prostate cancer progression and drug resistance.

Session Chair: Yates P, Supporting health professionals Session, Cancer Nurses Society of Australia 16th Winter Congress, Brisbane, 26 July 2013.

Invited speaker: Yates P. Evaluating complex interventions: The case of theProstate Cancer Specialist Nurse. ANZUP Annual Scientific Meeting, Gold Coast, 14 - 16 July 2013.

Poster presentation: Clements J, Herington A, Beatson International Cancer Conference, Glasgow, Scotland, 1 – 10 July 2013.

Invited presentation: Wagholikar A. Challenges in Improving Chronic Disease Survivorship Outcomes using Tele-health and Self-managed Online Solutions, IEEE EMBC Conference 2013, Osaka, Japan, 3-7 July 2013.

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