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Translational Research

Presentations 2014

In 2014, APCRC-Q research fellows and students presented at the following national and international conferences:

Oral: Levrier C, Sadowski MC, Nelson CC, Davis RA. Phytochemical and biological investigation of Denhamia celastroides, Brisbane Biological & Organic Chemistry Symposium, Brisbane, 1 December 2014.

Five presentations at the Australian Metastasis Research Society (OzMRS) Cancer Therapeutics Workshop, Melbourne, 1 December 2014:

Podium: Hollier BG. Revealing the landscape of epithelial-mesenchymal plasticity in prostate cancer metastasis.

Poster: Bock N, Hutmacher DW, Loessner DA, Clements JA. 3D Bioengineered Models for Prostate Cancer Bone Metastasis.

Poster: Kryza T, Tevz G, McPherson S, Lehman M, Stephens C, Nelson C, Clements J. Modulation of protease expression in prostate cancer cells after androgen deprivation.

Poster: Sweeney K, Stylianou N, Tevz G, McPherson S, Pirlo K, Upadhyaya A, Lehman M, Fazli L, Gleave M, Gunter J, Williams ED, Nelson CC, Hollier BG. Elucidating the role of Zeb1 in metastatic castration resistant prostate cancer.

Poster: Upadhyaya A, Stylianou N, Hollier BG, Williams ED. Targeting EMT to modulate prostate cancer cell chemoresistance.

Oral: Ling P, Breaking the communication code between prostate cancer cells and the adipocytes, TRI Cancer Seminar, Brisbane, 27 November 2014.

Invited presentation: Hollier BG, Promising new therapeutic target for prostate cancer metastases, TRI Awards Symposium, Brisbane, Queensland, 21 November 2014.

Poster: Tang K, Holzapfel BM, Liu J, Lee T K-W, Ma S, Jovanovic L, An J, Russell PJ, Clements JA, Hutmacher DW, Ling P. Tie-2 regulates the stemness and metastatic properties of prostate cancer cells, 26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics (ENA 2014), Barcelona, Spain, 18 - 21 November 2014.

Oral: Gunter J. Insulin in prostate cells: rationalizing current metabolic therapies in advanced cancer, TRI Cancer Seminar, Brisbane, 13 November 2014.

Invited speaker: Williams ED. Tumour plasticity contributes to disease progression in urological cancers, 4th International Conference for Cellular Dynamics and Chemical Biology, Hefei, China, 13 - 15 November 2014.

Poster: Tang K, Holzapfel BM, Liu J, Lee T K-W, Ma S, Jovanovic L, An J, Russell PJ, Clements JA, Hutmacher DW, Ling P. Tie-2 regulates the stemness and metastatic properties of prostate cancer cells, 10th NCRI Cancer Conference, Liverpool, United Kingdom, 2 - 5 November 2014.

Poster: Levrier C, Sadowski MC, Nelson CC, Davis RA. Phytochemical and biological investigation of Denhamia celastroides, 8th International Conference on Biodiversity and 28th International Symposium on the Chemistry of Natural Products, Shanghai, China, 20 – 24 October 2014.

Oral: Levrier C, Sadowski MC, Nelson CC, Davis RA. Phytochemical and biological investigation of Denhamia celastroides, Eskitis/Sino International Conference Modern Appropaches to Traditional Chinese Medicines, Shanghai, China, 16 – 17 October 2014.

Oral: Tevz G. Co-targeting relaxin and androgen signaling in prostate cancer, TRI Cancer Seminar, Brisbane, 16 October 2014.

Fourteen presentations at the Translational Research Institute Poster Symposium, Brisbane, 16 October 2014:

Oral: Batra J, Stegeman S, Klein K, Moya L, PRACTICAL Consortium, Spurdle AB, Clements JA. Genome-wide association studies of MiRSNPs identify novel prostate cancer risk loci.

Poster: Mosaad E, Chambers K, Clements J, Doran M. Differential migration of metastatic prostate cancer cells to bone marrow stromal cells.

Poster: Shah E, Ratther E, Tang T, Stylianou N, Gunter J, Williams E, Nelson C, Hollier B. Repositioning “old” drugs for new causes: identifying new treatments for prostate cancer.

Poster: Lisle J, Maharaj M, Mertens-Walker I, Stephens C, Stansfield S, Herington A, Clements J, Stephenson S-A. Proteolysis of the EphB4 receptor in prostate cancer; does it produce bioactive cleavage fragments?

Poster: Tang KD, Ling P. Tie-2 regulates the stemness of prostate cancer cells.
Poster: Liberio MS, Sadowski MC, Rockstroh A, Davis RA, Nelson CC. BDX1: A natural small molecule activator of the amino acid stress response pathway in prostate cancer cells.

Poster: Stylianou N, Jovanovic L, Lehman M, Wang C, Kashyap A, Costa T, Pirlo K, Tse B, Tevz G, McPherson S, Williams ED, Gunter J, Nelson CC, Hollier BG. Investigating the role of the epithelial-to-mesenchymal plasticity in prostate cancer metastasis.

Poster: Panchadsaram J, Tevz G, Nelson CC, Clements J, Batra J. Regulation of IRX4 and its anti-sense lncRNA NONHSAG039687 by androgens in prostate cancer.

Poster: Srinivasan S, Stephens C, Spurdle A, Clements J, Batra J. Functional analysis of the KLK3 variants, found to be associated with prostate cancer risk.

Poster: Jeet V, Rockstroh A, Tevz G, Lehman M, Russell P, Hollier B, Nelson C. Targeting YKL40: a novel approach to curb angiogenesis in metastatic prostate cancer.

Poster: Sagar Y, Maharaj M, Lisle J, Stephenson SA, Thier R. Glutathione transferases are variably contained within exosomes of prostate cancer cells.

Poster: Thomas P, Seim I, Walpole C, Jeffery P, Jovanovic L, Herington A, Nelson C, Whiteside E, Chopin L. The ghrelin receptor antisense gene, GHSROS, a long non-coding RNA involved in prostate cancer progression.

Poster: Levrier C, Sadowski MC, Davis RA, Nelson CC. Mechanism of action studies in prostate cancer cells on new compounds isolated from an Australian endemic rainforest tree.

Poster: Upadhyaya A, Stylianou N, Hollier BG, Williams ED. Targeting EMT to Modulate Prostate Cancer Cell Chemoresistance.

Poster: Rhee H. Repurposing Metformin in fight against prostate cancer, Urological Society of Australia and New Zealand (USANZ) Northern Meeting, Noosa, 10 – 12 October 2014.

Poster: Levrier C, Sadowski MC, Davis RA, Nelson CC. Mechanism of action studies in prostate cancer cells on new compounds isolated from an Australian endemic rainforest tree, Brisbane Cell and Developmental Biology Meeting, Brisbane, 26 September 2014.

Eighteen presentations at the 15th Asia-Pacific Prostate Cancer Conference 2014, Melbourne, 30 August – 2 September 2014:

Oral and Poster: Sadowski MC, Lubik AA, Locke JA, Hendy S, Moeinvaziri F, Davies J, Nelson CC. Inhibition of fatty acid synthase suppresses androgen signaling in LNCaP cells.

Oral and Poster: Liberio MS, Sadowski MC, Rockstroh A, Davis RA, Nelson CC. BDX1: A natural small molecule activator of the amino acid stress response pathway in prostate cancer cells.

Oral and Poster: Tse B, Stylianou N, Ratther E, McPherson S, Costa T, McGowan K, Lehman M, Fazli L,  Russell P, Gunter J, Williams E, Nelson C, Hollier B. Targeting neuropilin-1 to inhibit prostate cancer metastasis and therapy resistance.

Oral and Poster: Tevz G, Hossain A, Jeet V, Bathgate R, Wade J, Nelson C. Co-targeting H2 relaxin and androgen signalling in prostate cancer.

Oral and Poster: Levrier C, Sadowski MC, Davis RA, Nelson CC. Mechanism of action studies in prostate cancer cells on new compounds isolated from an Australian endemic rainforest tree.

Oral and Poster: Shah ET, Stylianou N, Gunter J, Williams E, Nelson C, Hollier B. Repositioning "Old" Drugs for New Causes: Identifying New Treatments for Metastatic Prostate Cancer.

Oral and Poster: Liberio MS, Sadowski MC, Rockstroh A, Vasireddy R, Davis RA, Nelson CC. The ascidian natural product EB activates DNA damage response pathways through inhibition of topoisomerase II in LNCaP cells.

Oral and Poster: Tang K, Ling P, Tie-2 regulates stemness and metastasis of prostate cancer cells.

Oral and Poster: Rockstroh A, Pokorny MR, Lehman M, Walker C, Nelson CC. YB-1, a driver of prostate cancer progression.

Oral and Poster: Soekmadji C, Russell PJ, Hill M, Riches J, Hanna I, Tamura K, Wang C, Rockstroh A, McPherson S, Nelson CC.  Androgen receptor influences the proliferation of prostate cancer cells through exosomes.

Oral and Poster: Srinivasan S, Stephens C, Spurdle A, Clements J; Batra J. Functional analysis of the KLK3 variants, found to be associated with prostate cancer risk.

Oral and Poster: Stegeman S, Lai J, Nelson C, Spurdle A, Clements J, PRACTICAL Consortium, Batra J. Association and functional analysis of miRSNP in prostate cancer - Result from the large collaborative oncological genetics studies (COGS).

Oral and Poster: Lai J, An J, Nelson CC, Kote-Jarai Z, Easton D, Amin A, Eeles RA on behalf of PRACTICAL consortium, Clements JA, Batra J. Identification of candidate functional short tandem repeats for analysis in large case-control prostate cancer risk studies.

Poster: Gunter JH, Lubik AA, Vasireddy R, Sarkar P, Hollier B, Herington A, Nelson CC. Defining the effect of metformin treatment in androgen deprived prostate cancer cells.

Poster: Sarkar PL, Gunter JH, Lubik AA, Stylianou N, Wang C, Hollier BG, Nelson CC. Androgen deprivation increases migration and invasion in prostate cancer cells and is increased by insulin.

Poster: Fung M, Eckert A, Nelson C. Clinical studies at the Australian Prostate Cancer Research Centre – Queensland.

Poster: Wagholikar A. Designing new health services for advanced prostate cancer patients: challenges and opportunities.

Poster: Eckert A, Williams E, Holzapfel B, Henkel J, Kelly J, Mellor I, Steck R, Hutmacher D, Nelson C, Clements J. Challenges and opportunities in establishing biobanking from a body donor program.

Podium: Vela I, Prostate Circulating Tumor Cell Culture, Thomas Ashworth CTC Symposium, Sydney, 7 August 2014.

Two presentations at the 13th International Conference on Bioinformatics, Sydney, 31 July - 2 August 2014:

Podium: Seim I, Walpole CM, Thomas PB, Jeffery PL, Fung JNT, Yap P-Y, O'Keeffe AJ, Lai J, Whiteside EJ, Herington AC, Chopin LK. Multi-species sequence comparison reveals conservation of preproghrelin splice variants and a novel variant encoding a truncated ghrelin peptide.

Poster: Lai J, An J, Seim I, Walpole C, Wang C, Lehman ML, Clements JA, Nelson CC, Batra J. Evaluation of fusion transcripts as markers of prostate cancer treatment resistance.

 Poster: Tse BWC, Cowin GJ, Soekmadji C, Jovanovic L, Vasireddy R, Ling P, Liu M, Khatri A, Thierry B, Russell PJ.  Prostate specific membrane antigen (PSMA)-targeting iron oxide magnetic nanoparticles enhance magnetic resonance imaging of preclinical prostate cancer, NanoBio Conference, Brisbane, 6-10 July 2014.

Poster: Stylianou N, Lehman M, Jovanovic L, Ratther E, Costa T, Kashyap A, Wang C, Gunter J, Williams ED, Nelson CC, Hollier BG. Revealing the landscape of epithelial-mesenchymal plasticity in metastatic castrate resistant prostate cancer, MRS 2014, 15th International Biennial Congress of the Metastasis Research Society, Heidelburg, Germany, 28 June - 1 July 2014.

Poster: Lisle J, Activation of membrane bound proteins and receptor systems: a link between tissue kallikrein and the KLK-related peptidases, Gordon Research Conference: Proteolytic enzymes and their inhibitors, Lucca, Italy, 22-27 June 2014.

Two presentations at the Endocrine Society's 96th Annual Meeting (ENDO 2014), Chicago, 21 – 25 June 2014:

Sarkar P, Gunter J, Lubik A, Stylianou N, Hollier B, Nelson C. Insulin increases migration and invasion in androgen deprived prostate cancer cells.
 
Thomas P, Walpole C, Seim I, Jeffery P, Jovanovic L, Herington A, Nelson C, Whiteside EJ, Chopin L. The long non-coding RNA GHSROS promotes proliferation and migration, and repression of immune response genes in cultured cancer cells.

Invited speaker: Nelson C,  Signal transduction, PCUK Biennial Prostate Cancer Forum, Baltimore, USA, 11-13 June 2014

Two oral and two poster presentations at the Australian Society for Medical Research (ASMR) Queensland Awards, Brisbane, 28-29 May 2014:

Oral: Batra J. Genome-wide association studies of miRSNPs identify novel prostate cancer risk loci (finalist in the Postdoctoral Researcher Award Category).

Oral: Bock N. Growth-factor loaded electrosprayed microparticles for targeted bone tissue regeneration (finalist in the Postgraduate Student Awards Category).

Poster: Sarkar, P.  Insulin Increases Invasion and Migration in Androgen Deprived Prostate Cancer cells.

Poster: Srinivasan S, Stephens C, Spurdle A, Clements J, Batra J. Functional analysis of a kallikrein variant, found to be associated with prostate cancer risk.

Poster: Yeadon T, Ensuring the Future Sustainability of a Disease Specific Biobank, International Society for Biological and Environmental Repositories (ISBER) conference, Florida, USA, 20-25 May 2014.

Two invited presentations at the Diamantina Health Partners Annual Forum, Brisbane, 1-2 May 2014:

Nelson C, Translation Stories: Science to care.

O’Byrne K, Breakfast Session panel member: Evidence and Innovation in clinical practice, and Lecture: Personalised Medicine in Oncology

Oral and Poster: Soekmadji C, Russell P, Hill M, McPherson S, Rockstroh A, Hanna I, Tamura K, Tse B, Dunne J, Jordan W, Nelson C. Exosomes Influence Proliferation of Androgen Sensitive Prostate Cancer Cells, International Society for Extracellular Vesicles (ISEV) 2014 Congress, Rotterdam, The Netherlands, 30 April – 3 May 2014.

An invited presentation and a poster presentation at the 10th Indo-Australian Conference on Biotechnology, Manipal, India, 11–13 April 2014:

Invited presention: Clements J Role of Kallikrein related peptidases in the tumor microenvironment.

Poster: Stegeman S, Lai J, Nelson C, Spurdle A, Clements J, PRACTICAL Consortium, Batra J, Association and functional analysis of miRSNPs in prostate cancer - Result from the large collaborative oncological genetics studies (COGS).

Poster: Tang KD. Tie-2 regulates stemness and metastasis of prostate cancer cells, 10th Annual Conference of the Organisation of Oncology and Translational Research (OOTR), Kuala Lumpur, Malaysia, 10–12 April 2014.

Two poster presentations at the American Association for Cancer Research Annual General Meeting, San Diego, USA, 5 – 9 April  2014:

Williams ED, Said NA, Gould CM, Thompson EW, Simpson KJ. High content multi-parametric functional screen for regulators of epithelial-mesenchymal transition identifies genes associated with chemoresistance.

Tang KD. Tie-2 regulates stemness and metastasis of prostate cancer cells.

One invited speaker and one poster presentation at the Cure Cancer Australia Researcher Symposium, Sydney, 25-26 March 2014:

Invited speaker: Gunter J, How does the metabolic syndrome contribute to prostate cancer progression and treatment resistance? Targeting hyperinsulinaemia in castrate resistant prostate cancer.

Poster: Stegeman S, Lai J, An J, Nelson C, Spurdle A, Clements J, PRACTICAL Consortium, Batra J, Genome-wide association studies of miRSNPs identify novel functional prostate cancer risk SNPs.

Three oral and one poster presentations at Urological Society of Australia and New Zealand (USANZ) Annual Scientific Meeting, Brisbane, 16 – 19 March 2014:

Oral: Tse B, Cowin G, Soekmadji C, Jovanovic L, Vasireddy R, Ling MT(P), Liu M, Khatri A, Thierry B, Russell P. Enhancing MRI of prostate cancer using PSMA-targeting iron oxide magnetic nanoparticles.

Oral: Jeet V, Hollier B, Nelson C, Targeting the Role of YKL40 in Metastatic Prostate Cancer.

Oral: Mertens-Walker I, Analysis of gene expression influenced by EphB4 identifies integrin β8 as simultaneously regulated in prostate cancer cells.

Poster: Soekmadji C, Russell P, Hill M, Dunne JC, Jordan TW, Nelson C. Androgen influence on prostate cancer secreted microvesicles production and content.

Invited speaker: Lehman M, Select Biosciences Next Generation Sequencing: Research to Clinic Agenda, San Diego, USA, 24 – 25 February 2014.

Oral: Fuhrman-Luck R, Lorne Proteomics Symposium, Victoria, 6 – 9 Feb 2014.

Poster: Yip S, Pavlakis N, Harvie R, Martin A, Jovanovic L, Hudson A, Thompson JF, Nelson C, Long A, Steer C, Harrison ML, Kannourakis G, Goldstein D, Kichenadasse G, Lowenthal RM, Stockler MR, Davis ID. Circulating biomarkers and outcomes in a single arm phase 2 trial of first line sunitinib alternating with everolimus for advanced renal cell carcinoma (aRCC) (EVERSUN ANZUP trial 0901), American Society of Clinical Oncology (ASCO) 2014 Genitourinary Cancers Symposium, San Francisco, USA, 30 January – 1 February 2014.

Poster: An J, Lai J, Lehman M, Nelson C. MiRNA Identification From RNA Sequencing Data, Twelfth Asia Pacific Bioinformatics Conference, Shanghai, China, 17 – 19 January 2014.

Two posters at American Association of Cancer Research, Advances in Prostate Cancer Research Conference, San Diego, USA, 18 – 21 January 2014:

Poster: Gunter J, Sarkar P Lubik A, Lehman M, Stylianou N, Hollier B, Nelson C. Insulin increases migration and invasion in androgen deprived prostate cancer cells.

Poster: White-Habeeb NMA, Olkhov-Mitsel E, Kron K, Pethe V, Lehman M, Jovanovic L, Fleshner N, van der Kwast T, Nelson CC, Bapat B. Integrated analysis of epigenomic and genomic changes regulated by DNA methylation dependent mechanisms provides potential novel biomarkers for prostate cancer.