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Grants

Metastatic prostate cancer and circulating tumour cell in vitro culture

The ability to grow metastatic prostate cells and Circulating Tumour Cells (CTCs) will provide multiple new model systems to investigate the mechanisms of cancer metastasis, identify new potential therapeutic targets and treatments, and from a precision medicine perspective, it may in the future provide an ability to tailor therapeutic decisions specific to each tumour prior to treating the patient. The potential utility of a "liquid biopsy" via culture, amplification and analysis of CTCs may avoid invasive biopsies of metastatic sites.

The aims of this project are:

  1. Establishment of organoid technology for metastatic prostate cancer tissue culture at PAH/APCRC-Q.
  2. Establishment of organoid technology for the culture, amplification and analysis of prostate cancer circulating tumour cells at PAH/APCRC-Q.
  3. Utilization of organoid culture technologies in Precision Medicine/Clinical Trials.

Investigators

Ian Vela APCRC-Q, IHBI, QUT, TRI & PAH

Duration

2015 - 2016

Funding