header-15
Grants

Investigation of the role of lymph node metastasis in initiation and progression of bone metastasis

This project will contribute to i) the understanding if cancer cells from prostate cancer patients with different phenotypes of disease induce comparable tumour-induced mineralization in a model of bone metastasis and ii) establish a model to identify key molecular mediators of prostate cancer-induced bone formation. The differences between lymph node and bone metastasis are not well studied. We don’t understand why some patients have only lymph node metastasis and some patients present with bone only or mixed metastasis. This study will help us to understand if there are specific interactions between prostate cancer phenotypes and bone cells which lead to bone metastasis. This information is critical to find targets to inhibit, prevent or treat metastasis.

Investigators

Ian Vela APCRC-Q, IHBI, QUT, TRI, PAH
Saeid Alinezhad APCRC-Q, IHBI, QUT, TRI
Elizabeth Williams APCRC-Q, IHBI, QUT, TRI
Dietmar Hutmacher APCRC-Q, IHBI, QUT, TRI

Administering Institution

Princess Alexandra Hospital

Duration

2018 - 2019

Funding

Metro South Health Research Support Scheme $75 000