This project will contribute to i) the understanding if cancer cells from prostate cancer patients with different phenotypes of disease induce comparable tumour-induced mineralization in a model of bone metastasis and ii) establish a model to identify key molecular mediators of prostate cancer-induced bone formation. The differences between lymph node and bone metastasis are not well studied. We don’t understand why some patients have only lymph node metastasis and some patients present with bone only or mixed metastasis. This study will help us to understand if there are specific interactions between prostate cancer phenotypes and bone cells which lead to bone metastasis. This information is critical to find targets to inhibit, prevent or treat metastasis.
