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About Us

Elizabeth Williams

Elizabeth Williams

Positions

  • Head, Tumour Models, APCRC-Q
  • Member, IHBI, QUT

Contact Details

Phone
+61 7 3443 7360

Qualifications

PhD, Parathyroid hormone-related protein and the female reproductive tract, University of Melbourne, Australia, 1997

BSc (Hons), University of Melbourne, 1991

Biography

Dr Elizabeth Williams, BSc (Hons), PhD, joined APCRC-Q in 2013 to lead the tumour models stream and extend her prostate cancer research program. She has worked in the field of cancer metastases, focussing on prostate and bladder cancer, since completing her PhD in pharmacology in 1997.

Prior to joining APCRC-Q, Dr Williams was the Metastasis Research Group Leader at Monash Institute of Medical Research’s Centre for Cancer Research (2006-2012), an Associate Senior Fellow at the Department of Surgery, University of Melbourne and a Research Fellow (Prostate Cancer Group Leader) at the Bernard O'Brien Institute of Microsurgery (2002-2006).

Dr Williams and her team have established a panel of systems to study the interaction of prostate cancer cells within the endothelial cells of the prostatic lymphatic vessels, with the aim of identifying key molecules involved in the process.

They are also investigating the molecular basis of prostate cancer cells that survive castration.  Her current research project utilises a transplantable human prostate cancer xenograft that her team derived from a bone metastasis in 2001.

Awards and grants

Awards

2008-2012

National Health and Medical Research Council Fellowship, Biomedical Career Development Award

2005

Best presentation (non-Consultant) Victorian Urology Meeting

2005

Inaugural Harold Story Lecturer, Austin Hospital

2004

Best presentation (Senior Scientist), St Vincent’s Hospital Research Week

1999

International Union Against Cancer ICRETT Fellowship ‘Molecular Mechanisms of Prostate Cancer Chemoprevention at the Division of Cancer Prevention and Advanced Technologies Center, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

1996

Melbourne University Postgraduate Scholarship

1996

Australian Postgraduate Award

Grants

2012-2013

Victoria Cancer Agency

The Cancer of Prostate Translational Research In Victoria (CAPTIV) Collaboration

M Frydenberg, ED Williams, et al.

2012-2013

Prostate Cancer Foundation of Australia

How do castrate resistant prostate cancer cells escape dormancy?

ED Williams

2010-2013

ARC Linkage Project

Designing dendrimer-based lymphatic drug vectors as improved treatments for metastatic cancer.

C. Porter, L. Kaminskas, B Boyd, ED Williams, D Owen

2010-2012

Cancer Council Victoria

Novel pharmacological targets for tumour angiogenesis

S. Selemidis, ED Williams, G Drummond.

2010-2011

Marian and E.H. Flack Trust

Can elemental bio-imaging of trace elements be used as a prognosis marker for prostate cancer?

S. Wilkins, ED Williams, P Doble, K Opeskin

2009-2011

CRC-Biomedical Imaging Development

Characterisation of a mouse prostate cancer model for tracer development.

ED Williams

2008-2012

NHMRC Fellowship Biomedical Career Development Award

Mechanisms of metastasis in urological cancers

ED Williams

2008-2010

NHMRC Project Grant

Mechanism of breast cancer metastasis: tumour cell remodelling of the extracellular matrix.

D. Russell, C Ricciardelli, E.D. Williams

2008-2009

Victoria Cancer Agency

Development of a high content screening platform for individualised cancer chemotherapy

ED Williams, DN Watkins, TG Johns, GE Hannigan, CE Gargett, ID Davis,

2008

Cancer Trusts (Equity Trustees)

A new target for treating cancer metastasis.

ED Williams

2007-2008

Cancer Council Victoria

 Mechanisms underlying prostate cancer lymph node metastasis

ED Williams, K Opeskin, C Temelcos

Research interests

Cancer metastases, breast cancer, prostate cancer, bone metastases, bladder cancer, cancer progression

Top publications

  • Lelekakis M, Moseley JM, Martin TJ, Hards D, Williams ED, Ho P, Lowen D, Javni J, Miller FR, Slavin J, and Anderson RL (1999). A novel orthotopic model of breast cancer metastasis to bone. Clinical and Experimental Metastasis, 17, 163-170.
  • Carlisle AJ, Prabhu VV, Elkahloun A, Hudson J, Trent JM, Linehan WM, Williams ED, Emmert-Buck MR, Liotta LA, Munson PJ, Krizman DB (2000) Development of a prostate cDNA microarray and statistical gene expression analysis package. Molecular Carcinogenesis, 28:12-22
  • McCulloch DR, Opeskin K, Thompson EW, Williams ED (2005) BM18: A novel androgen dependent human prostate cancer xenograft model derived from a bone metastasis. The Prostate, 65:35-43
  • Chaffer CL, Thomas DM, Thompson EW, Williams ED (2006) PPARgamma-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma. BMC Cancer, 6: 53
  • Yu L, Yuan X, Barakat B, Williams* ED, Hannigan* GE. Selective regulation of p38beta protein and signaling by integrin-linked kinase mediates bladder cancer cell migration. Oncogene, accepted for publication January 2013. *co-senior author

Professional memberships and associations

Member, American Association of Cancer Research

Member, Australian Society for Medical Research

Member, Australian Prostate Cancer Collaboration

Member, Metastasis Research Society (International)

Member, The EMT International Association

Member, Urological Society of Australia and New Zealand

Upcoming Events

Apr 13, 2019 - Apr 16, 2019 USANZ 2019
Brisbane Convention and Exhibition Centre