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Grants

Identification of RNA species regulated by YB-1 and G3BPs in prostate cancer cells

The major obstacle for successful treatment of advanced prostate cancer is the development of androgen independence and therapeutic resistance during cancer progression. Identifying the molecular mechanisms underlying these processes is crucial to developing novel therapeutic strategies that make a significant impact on patient survival. Stress-activated proteins have been identified as key factors in the development of therapeutic resistance and have already been proven to be promising targets for novel treatment strategies in prostate cancer. The stress-activated proteins YB-1 and G3BP are known to be biomarkers of poor prognosis and are promising candidates to become therapeutic targets, too. Since they are multifunctional proteins, their inhibition could affect multiple mechanisms and pathways important for cancer progression. The increasing evidence from the Centre’s lab linking elevated YB-1 levels with androgen independence and chemotherapeutic resistance makes especially YB-1 an excellent target for therapeutic treatment. Investigating the function of YB-1 and G3BPs and their downstream pathways with respect to mechanisms of cancer progression will help to identify novel therapeutic targets for advanced prostate cancer.

Investigators

Colleen Nelson APCRC-Q, IHBI, QUT, TRI
Derek Kennedy Eskitis Institute for Drug Discovery, Griffith University
Anja Rockstroh APCRC-Q, IHBI, QUT, TRI

Duration

2011 - 2012

Funding

Upcoming Events

Jul 19, 2020 - Jul 21, 2020 ANZUP 2020 Annual Scientific Meeting
Adelaide Convention Centre, South Australia
Aug 18, 2020 - Aug 21, 2020 PA Hospital Health Symposium
Russell Strong Auditorium, Princess Alexandra Hospital, 199 Ipswich Rd, Woolloongabba
Aug 21, 2020 - Aug 23, 2020 21st Asia-Pacific Prostate Cancer Conference
Melbourne Convention and Exhibition Centre, Victoria
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