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About Us

Anja Rockstroh

Anja Rockstroh

Positions

  • Postdoctoral Research Fellow, APCRC-Q
  • Member, IHBI, QUT

Contact Details

Phone
+61 7 3443 7277

Qualifications

  • Doctor of Science, Human topoisomerase I and genotoxic stress, Friedrich-Schiller University in Jena, Germany, 2007
  • Diploma in Biochemistry, Friedrich-Schiller University, 2002

Biography

Dr. Rockstroh received her Diploma in Biochemistry from Friedrich-Schiller University Jena, Germany where she went on to obtain a Doctor of Science degree for her work on Human topoisomerase I and genotoxic stress.

As a Research Fellow at Griffith University’s Eskitis Institute for Cell and Molecular Therapies, she investigated a potential role of G3BPs in proliferation control and cancer development and progression before leaving to join APCRC-Q as a Research Fellow in early 2010.

Dr. Rockstroh’s current research is focussed on the role played by stress-activated proteins, YB-1 and G3BP in androgen independent and chemotherapeutic resistant prostate cancer. YB-1 and G3BP are known to be biomarkers of poor prognosis and are promising candidates to become therapeutic targets, and, since they are multifunctional proteins, their inhibition could affect multiple mechanisms and pathways important for cancer progression.

Investigating the function of YB-1 and G3BPs and their downstream pathways with respect to mechanisms of cancer progression will help to identify novel therapeutic targets for advanced prostate cancer.

Awards and grants

Grants

2011 - 2013 Prostate Cancer Foundation of Australia Identification of RNA species regulated by YB-1 and G3BPs in prostate cancer cells Nelson C, Kennedy D, Rockstroh A

Research interests

cellular stress response, RNA binding proteins, cell cycle and proliferation control, apoptosis

Current research projects

Therapeutics

Investigating the role of stress activated RNA binding proteins in prostate cancer progression

    Top publications

    • Rockstroh A, Kleinert A, Kramer M, Grosse F and Søe K. Cellular stress triggers the human topoisomerase I damage response independently of DNA damage in a p53 controlled manner, Oncogene, 2007;26(1):123-31
    • Søe K, Rockstroh A, Grosse F. Role of Human Topoisomerase I in DNA Repair and Apoptosis, Genome Integrity; Facets and Perspectives; Series: Genome Dynamics & Stability Vol. 1; Lankenau, D.H. (Ed.) 2006, Due: November 7, 2006 – Book chapter Springer-publishing Berlin / Heidelberg, ISBN: 3-540-37528-7
    • Søe K, Rockstroh A, Schache P and Grosse F. The human topoisomerase I damage response plays a role in apoptosis, DNA Repair (Amst). 2004;3(4):387-93

    Collaborators

    • Dr Derek Kennedy, Chief Investigator, Cancer Biology, Griffith Institute of Drug Discovery