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Grants

Global Collaborative Xenografting Project

This collaborative project involves 30 investigators across 7 countries.  The multi-disciplinary team of internationally recognised scientists has expertise in the combined areas of:

  • prostate xenograft establishment and their phenotypic annotation,
  • Tissue Micro-Array construction and characterization
  • genetic analysis and annotation.

The project aims to:

  • Establish a phenotypic description of existing prostate cancer patient derived xenografts, protocol optimization and gap analysis.
  • Develop new patient derived xenografts according to the optimized standard operating procedures with a focus on prostate cancer phenotypes that are not well represented in the existing patient derived xenografts.

The main objectives of this project are to obtain high quality patient derived xenografts from men with hormone naïve and treatment resistant prostate cancer from primary sites at different clinical stages (e.g. locally advanced metastatic) as well as from metastases to construct Tissue Micro-Arrays and new xenograft models that will become an important resource to study therapy response/resistance and biomarker discovery.

The Tissue Micro-Arrays will allow the identification of biomarker expression differences within and between patient derived xenografts. Data collected from this study will be published and made available, together with its corresponding clinical information, to the prostate cancer research community. New patient derived xenografts will expand the repertoire of resources that underpin prostate cancer research, and particularly preclinical testing.

Investigators

Elizabeth Williams APCRC-Q, IHBI, QUT, TRI
Pamela Russell APCRC-Q, IHBI, QUT, TRI
Colleen Nelson APCRC-Q, IHBI, QUT, TRI

Duration

2014 - 2016

Funding

Movember Global Action Plan 1 $112 500

 

Upcoming Events

Jul 19, 2020 - Jul 21, 2020 ANZUP 2020 Annual Scientific Meeting
Adelaide Convention Centre, South Australia
Aug 18, 2020 - Aug 21, 2020 PA Hospital Health Symposium
Russell Strong Auditorium, Princess Alexandra Hospital, 199 Ipswich Rd, Woolloongabba
Aug 21, 2020 - Aug 23, 2020 21st Asia-Pacific Prostate Cancer Conference
Melbourne Convention and Exhibition Centre, Victoria
Sep 29, 2020 - Oct 02, 2020 ComBio 2020
Melbourne Convention and Exhibition Centre, Victoria
Nov 11, 2020 - Nov 13, 2020 COSA Annual Scientific Meeting
Brisbane Convention and Exhibition Centre, Queensland