Global Collaborative Xenografting Project
This collaborative project involves 30 investigators across 7 countries. The multi-disciplinary team of internationally recognised scientists has expertise in the combined areas of:
- prostate xenograft establishment and their phenotypic annotation,
- Tissue Micro-Array construction and characterization
- genetic analysis and annotation.
The project aims to:
- Establish a phenotypic description of existing prostate cancer patient derived xenografts, protocol optimization and gap analysis.
- Develop new patient derived xenografts according to the optimized standard operating procedures with a focus on prostate cancer phenotypes that are not well represented in the existing patient derived xenografts.
The main objectives of this project are to obtain high quality patient derived xenografts from men with hormone naïve and treatment resistant prostate cancer from primary sites at different clinical stages (e.g. locally advanced metastatic) as well as from metastases to construct Tissue Micro-Arrays and new xenograft models that will become an important resource to study therapy response/resistance and biomarker discovery.
The Tissue Micro-Arrays will allow the identification of biomarker expression differences within and between patient derived xenografts. Data collected from this study will be published and made available, together with its corresponding clinical information, to the prostate cancer research community. New patient derived xenografts will expand the repertoire of resources that underpin prostate cancer research, and particularly preclinical testing.
