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Grants

Using Bioengineered 3D Models to Replicate the Tumour Microenvironment in Prostate Cancer

In cancers where adipocytes constitute a major component of the microenvironment, cancer cells are known to promote uncontrolled tumour growth. The hypothesis of this project is that this is also true and significant for castrate-resistant prostate cancer (CRPC) bone metastasis, due to the high adipocyte content in the bone marrow of patients with CRPC. This project will address this hypothesis by using established 3D in vitro and in vivo bone metastatic models, and add adipocytes, to study their effect on the prostate cancer-bone crosstalk and identify therapeutic targets.

The aims of the project are:

  1. Determine the functional impact of an adiposity-enriched 3D bone microenvironment on prostate cancer cell function and metastasis and vice versa, in vitro and in vivo.
  2. Pre-clinical screening of therapeutic drugs using a humanised bone metastatic niche in vivo.

Investigators

Nathalie Bock APCRC-Q, IHBI, QUT, TRI

Duration

2015 - 2018

Funding

NHMRC Fellowship $309 436

Upcoming Events

Jul 19, 2020 - Jul 21, 2020 ANZUP 2020 Annual Scientific Meeting
Adelaide Convention Centre, South Australia
Aug 18, 2020 - Aug 21, 2020 PA Hospital Health Symposium
Russell Strong Auditorium, Princess Alexandra Hospital, 199 Ipswich Rd, Woolloongabba
Aug 21, 2020 - Aug 23, 2020 21st Asia-Pacific Prostate Cancer Conference
Melbourne Convention and Exhibition Centre, Victoria
Sep 29, 2020 - Oct 02, 2020 ComBio 2020
Melbourne Convention and Exhibition Centre, Victoria
Nov 11, 2020 - Nov 13, 2020 COSA Annual Scientific Meeting
Brisbane Convention and Exhibition Centre, Queensland