header-13
Grants

The ghrelin receptor antisense long non-coding RNA gene, GHSROS, as a potential target for prostate cancer therapy

The specific aims that will be addressed in this study are:

  1. To characterise the subgroup of clinical prostate cancers which express high levels of GHSROS using RNA in situ hybridisation and quantitative RT-PCR in order to correlate expression with clinical data and outcomes;

  2. To investigate the role of GHSROS in tumour growth, invasion and metastasis using orthotopic (intraprostatic) xenograft models; and

  3. To investigate the effect of GHSROS silencing on prostate tumour growth in vivo using a xenograft model and locked nucleic acid antisense oligonucleotides.

 

Investigators

Lisa Chopin APCRC-Q, IHBI, QUT, TRI
Inge Seim APCRC-Q, IHBI, QUT, TRI
Adrian Herington APCRC-Q, IHBI, QUT, TRI
Rakesh Veedu The University of Queensland

Duration

2016 - 2017

Funding

Cancer Council Queensland $200 000