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Grants

Revolutionary Team Award 3 - exploiting alterations in lipid metabolism to improve diagnosis, treatment and molecular imaging of prostate cancer

Altered lipid metabolism is an androgen- and obesity-regulated process in prostate tumour cells that can be used as a source of biomarkers in (i) patients with low-volume localised disease to predict, at the time of diagnosis, whether an individual patient has indolent or aggressive disease; and (ii) patients with high-risk localised prostate cancer to detect clinical responses to androgen receptor (AR) targeting therapies in neoadjuvant and adjuvant clinical trials.

The aims of the program are:

  1. To define signatures of lipid profiles that are correlated with prostate cancer aggressiveness and response to androgen targeted therapy.
  2. To investigate the effects of androgens and obesity on lipid metabolism in prostate cancer.

  3. To convert prostate lipid profiles into non-invasive detection modalities.

 

Investigators

Lisa Butler University of Adelaide
Wayne Tilley University of Adelaide
Andrew Hoy University of Sydney
Gary Wittert University of Adelaide
Colleen Nelson  APCRC-Q, IHBI, QUT, TRI
Andrew Scott Ludwig Cancer Institute, Melbourne
John Swinnen University of Sydney
Andrew Weickhardt Warringal Private Hospital
Ian Davis Monash University
Carl Power University of New South Wales
Tina Bianco-Miotto University of Adelaide
Pamela Russell  APCRC-Q, IHBI, QUT, TRI
David Brooks Imperial College London, England
Peter Sutherland Royal Adelaide Hospital
Francis Parnis Adelaide Cancer Centre

Administering Institution

University of Adelaide

Duration

2015 - 2018

Funding

PCFA Movember Revolutionary Team Award $3 250 000