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Grants

KLK14 as a novel therapeutic target in muscle wasting induced by androgen deprivation therapy

This project aims to determine if the PSA-related protease, KLK14, induces muscle wasting in men on androgen deprivation therapy (ADT) and determine the underlying mechanisms involved in this process.

  This study will determine:

  1. the expression levels of KLK14 in muscle biopsies from men with prostate cancer, both ADT treatment naive and on ADT;

  2. the regulatory response of KLK14 in a human skeletal muscle cell line to androgen stimulation (DHT) and the anti-androgens, bicalutamide and enzalutamide to mimic the clinical ADT setting;

  3. the mechanisms of KLK14 mRNA induction and downstream consequences of KLK14 action that drives the skeletal muscle microenvironment remodelling in ADT.

 

Investigators

Judith Clements APCRC-Q, IHBI, QUT, TRI

 

Duration

2016 - 2016

Funding

Prostate Cancer Foundation of Australia $99 732