Investigating the biological response to stereotactic radiation in oligometastatic prostate cancer

Our objective is to characterise the radiobiology and biological response of bone tissue and prostate tumours in response to stereotactic body radiotherapy (SBRT) applied to prostate cancer xenograft models of metastatic tumour growth within bone. To achieve this we will undertake the following aims:

  1. Investigate SBRT dose and fractionation for effects on tumour and bone response using prostate cancer intratibial tumour models with differential bone-interacting phenotypes +/-ADT.

  2. Use optimised does of SBRT in the context of ADT to test the co-effect of bisphosphonates (zolendronic acid) and radiosensitisers (Nimorazole) on bone remodelling and tumour response.



Colleen Nelson APCRC-Q, IHBI, QUT, TRI
David Pryor APCRC-Q, PAH
Margot Lehman PAH
Elizabeth Williams APCRC-Q, IHBI, QUT, TRI
Andrew Fielding QUT


2016 - 2016


PA Research Support Scheme $50 000

Upcoming Events

Jul 19, 2020 - Jul 21, 2020 ANZUP 2020 Annual Scientific Meeting
Adelaide Convention Centre, South Australia
Aug 18, 2020 - Aug 21, 2020 PA Hospital Health Symposium
Russell Strong Auditorium, Princess Alexandra Hospital, 199 Ipswich Rd, Woolloongabba
Aug 21, 2020 - Aug 23, 2020 21st Asia-Pacific Prostate Cancer Conference
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