High-content screening of small molecule inhibitors from nature that target prostate cancer metabolism
This project will screen and evaluate a library of 472 novel compounds that were isolated from Australian plants, fungi and marine organisms for their inhibitory activity on several metabolic pathways critical for prostate cancer growth and survival. This project will identify new metabolic inhibitors from nature, provide valuable insights for future large-scale cancer metabolism screens, generate knowledge about regulatory pathways of cancer metabolism and inform and inspire the development of new anticancer agents from nature.
Investigators
| Rohan Davis | Griffith Institute for Drug Discovery, APCRC-Q |
| Colleen Nelson | APCRC-Q, IHBI, QUT, TRI |
| Martin Sadowski | APCRC-Q, IHBI, QUT, TRI |
| Jennifer Gunter | APCRC-Q, IHBI, QUT, TRI |
Administering Institution
Griffith University
Duration
2017 - 2017
Funding
| Prostate Cancer Foundation of Australia | $99618 |
