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Grants

Global Action Plan 4 - INTense Exercise foR surVivAL among men with Metastatic Castrate-Resistant Prostate Cancer (INTERVAL – MCRPC)

A Multicenter, Randomized, Controlled, Phase III Study

The primary aims of the Movember GAP4 project are to establish an optimal exercise protocol to maximize quality of life and survival of men with advanced prostate cancer, and to unravel the molecular mechanisms underpinning the beneficial effects of exercise in men with advanced disease.

INTERVAL-MCRPC is a randomised controlled trial (RCT) designed to determine if high intensity aerobic and resistance training plus psychosocial support increases overall survival compared to psychosocial support alone in patients with metastatic castrate-resistant prostate cancer. The study also aims to:

    • To compare time to disease progression between the intervention and control groups.

    • To compare the time to first occurrence of a symptomatic skeletal-related event between the intervention and control groups.

    • To compare time to progression of pain, degree of pain, and opiate use between the intervention and control groups.

    • To compare change in levels of inflammation, energy metabolism, and androgen metabolism biomarkers between the intervention and control groups over time.

    • To determine whether biomarkers of inflammation, energy metabolism, and androgen metabolism are associated with overall survival and explore the extent to which these biomarkers mediate the hypothesized association between exercise and overall survival.

    • To compare physical and emotional quality of life between the intervention and control groups

 

Investigators

Colleen Nelson APCRC-Q, IHBI, QUT, TRI
Pretoria  Bilinski Greenslopes Private Hospital
Alistair Campbell East Coast Urology
David Sillar East Coast Urology
Stephen Bourne East Coast Urology
Jeffrey Coombes The University of Queensland
Katherine Cuff PAH
Jennifer Gunter APCRC-Q, IHBI, QUT, TRI
Kenneth Ho PAH
Justin Keogh Bond University
Margot Lehman PAH
Sumit Lumba John Flynn Hospital, Tweed Heads Hospital
Tina Skinner The University of Queensland
Christopher Tracey Gold Coast Urology, Gold Coast University Hospital, Pindara Private Hospital
Ian Vela APCRC-Q, IHBI, QUT, TRI

Duration

2016 - 2018

Funding

Movember Foundation