Establishing a 3D in vitro model to replicate the tumour microenvironment in advanced prostate cancer bone metastasis
The overall objective is to develop bioengineered in vitro metastatic models that include adipocytes in a 3D bone microenvironment, in order to study the prostate cancer-bone crosstalk in an androgen deprivation therapy (ADT) context and identify therapeutic targets to complement ADT, with a focus on bone metastasis.
The hypothesis of this project is that the high bone marrow adipocyte content in the bone marrow of men undergoing ADT constitutes a significant component of the bone microenvironment, which helps to regulate prostate cancer progression and bone metastasis.
Duration
2015 - 2017
Funding
| Institute of Health and Biomedical Innovation, QUT (July 2015 - June 2016) |
$9 995 |
| PCFA John Mills Young Investigator Award (October 2016 - September 2017) |
$98 561 |
