Establishing a 3D in vitro model to replicate the tumour microenvironment in advanced prostate cancer bone metastasis

The overall objective is to develop bioengineered in vitro metastatic models that include adipocytes in a 3D bone microenvironment, in order to study the prostate cancer-bone crosstalk in an androgen deprivation therapy (ADT) context and identify therapeutic targets to complement ADT, with a focus on bone metastasis.

The hypothesis of this project is that the high bone marrow adipocyte content in the bone marrow of men undergoing ADT constitutes a significant component of the bone microenvironment, which helps to regulate prostate cancer progression and bone metastasis.



Nathalie Bock APCRC-Q, IHBI, QUT, TRI


Judith Clements APCRC-Q, IHBI, QUT, TRI


2015 - 2017


Institute of Health and Biomedical Innovation, QUT
(July 2015 - June 2016)
$9 995
PCFA John Mills Young Investigator Award
(October 2016 - September 2017)
$98 561

Upcoming Events

Jul 19, 2020 - Jul 21, 2020 ANZUP 2020 Annual Scientific Meeting
Adelaide Convention Centre, South Australia
Aug 18, 2020 - Aug 21, 2020 PA Hospital Health Symposium
Russell Strong Auditorium, Princess Alexandra Hospital, 199 Ipswich Rd, Woolloongabba
Aug 21, 2020 - Aug 23, 2020 21st Asia-Pacific Prostate Cancer Conference
Melbourne Convention and Exhibition Centre, Victoria
Sep 29, 2020 - Oct 02, 2020 ComBio 2020
Melbourne Convention and Exhibition Centre, Victoria
Nov 11, 2020 - Nov 13, 2020 COSA Annual Scientific Meeting
Brisbane Convention and Exhibition Centre, Queensland