During this fellowship program Dr Hollier will undertake a four month exchange visit to the Vancouver Prostate Centre under the supervision of Prof Ralph Buttyan. During this exchange he will conduct research to better understand key biological processes underpinning the transition of prostate cancer from a relatively indolent and curable state into one that is resistant to contemporary therapies and the major cause of mortality. This research brings together two innovative and unique models of epithelial plasticity developed by Dr Hollier and Prof Buttyan to provide a first ever analysis of critical tumour cell adaptive responses to anti-cancer therapies. Targeting key drivers of epithelial plasticity will lead to the development of novel and effective treatments for prostate cancer progression and therapy resistance.