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About Us

Patrick Ling

Patrick Ling

Positions

  • Head, Laboratory of Cancer Therapeutic Development, APCRC-Q
  • Vice Chancellor Fellow, IHBI, QUT
  • Honorary Assistant Professor, The University of Hong Kong

Contact Details

Phone
+61 7 3443 7239

Qualifications

  • Postdoctoral Cancer Biology, The University of Hong Kong, 2006
  • PhD Cancer Biology, The University of Hong Kong, 2003
  • M Phil Cancer Biology, The University of Hong Kong, 2000
  • BSc Biochemistry, The Hong Kong University of Science and Technology, 1997

Biography

Dr Ling obtained his Bachelor degree in the Department of Biochemistry at The Hong Kong University of Science and Technology. He was awarded his MPhil and PhD degrees at The University of Hong Kong, and, in 2005, received the Outstanding Research Postgraduate Award. He was a postdoctoral research fellow in the Department of Anatomy at The University of Hong Kong, and was promoted to Research Assistant Professor in the same department.

He is currently a Senior Research Fellow in the Institute of Health and Biomedical Science and the Australian Prostate Cancer Research Centre-Queensland where he heads up an ongoing research program that aims to thoroughly investigate the key factors/mechanisms that promote cancer stem cell-mediated prostate cancer bone metastasis, with the ultimate goal of developing effective treatments against this deadly disease. Cancer Stem Cells (CSCs) are now considered to be the missing pieces in the search for better cures for different types of cancer, including prostate cancer.

Dr Ling’s lab is one of the world’s leading teams studying the anti-cancer effect of natural compounds such as tocotrienol and was the first to discover its potent effect against CSC populations. Currently, with the support of two National Health and Medical Research Council (NHMRC) project grants as Principal investigator, his team is investigating a fundamental research questions in this field: How does the cancer stem cells managed to escape from the primary tumour and disseminated into the secondary tissue such as the bone? Through these projects, the team has identified a number of key signalling pathways that promote the vascular dissemination of prostate cancer cells and the eventual development of bone metastasis. In collaboration with the Eskitis Institute, which owns a natural compound library of over two hundred thousand extracts, Dr Ling’s team is currently undertaking an innovative approach of incorporating a novel co-culture model into a high-throughput screening platform for identification of natural compounds which has the potential of targeting cancer stem cells that reside within the tumour-microenvironment.

He has published a total of 71 publications (>1,700 citations; H-index 26). He relocated to Australia in 2009 when he was awarded the QUT Vice Chancellor’s Senior Research Fellowship to establish a translational research team at the APCRC-Q. He is currently the CIA on 2 NHMRC project grants and a commercial collaboration with Davos Life Science PL. He is also the Co-PI of a Malaysian Government grant ($2.2M) for a clinical trial. Overall, he has secured more than $3.6M in research funding, not only from national and overseas funding agencies but also from industrial partners.

Research interests

prostate cancer, chromosome instability, hormone refractory, natural food compound, cancer stem cell

Current research projects

Biomarkers

Identify Biomarkers to Discriminate Indolent from Aggressive Prostate Cancer and Mechanisms of Therapeutic Resistance

    Top publications

    • Luk SU, Yap WN, Chiu YT, Lee DTW, Ma S, Lee TKW, Wong YC, Ching YP, Yap YL, Ling MT. Gamma-Tocotrienol as an effective agent in targeting prostate cancer stem cell-like population. International Journal of Cancer. 2011; 128:2182-91.
    • Ling MT, Tay D, Cheung W, Ellis-Behnke R. Using self-assembled nanomaterials to delay the formation of metastatic cancer cell colonies in vitro. Cell Transplantation. 2011; 20:127-31.
    • Luk SU, Lee TKW, Lee DTW, Chiu YT, Ma S, Ng IOL, Wong YC, Chan FL and Ling MT. Chemopreventive effect of PSP through targeting of prostate cancer stem cell-like population. PLoS One. 2011; 6:e19804.
    • Ma S, Chan YP, Kwan PS, Lee TK, Yan M, Tang KH, Ling MT, Vielkind JR, Guan XY, Chan KW. MicroRNA-616 Induces Androgen-Independent Growth of Prostate Cancer Cells by Suppressing Expression of Tissue Factor Pathway Inhibitor TFPI-2. Cancer Res. 2011; 71:583-592.
    • Chen J, Zhang B, Wong N, Lo AW, To KF, Chan AW, Ng MH, Ho CY, Cheng SH, Lai PB, Yu J, Ng HK, Ling MT, Huang AL, Cai XF, Ko BC. Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth. Cancer Res. 2011; 71:4138-49
    More publications are available on PubMed

    Team

    • Ji Liu Research Assistant, APCRC-Q
    • Kaidun Tang, PhD Candidate, APCRC-Q
    • Alice Wilce, Masters Student, APCRC-Q

    Collaborators

    • Prof Kum Kum Khanna, QIMR
    • Prof Ron Quinn, Eskitis Institute
    • Dr Harendra Parekh, UQ
    • Prof Franky Chan, The Chinese University of Hong Kong
    • Dr Terence Lee, The University of Hong Kong
    • Dr Stephanie Ma, The University of Hong Kong

    Professional memberships and associations

    Current Academic Editor, PLoS One
    Current Editor, Chinese Journal of Clinicians
    Current Member, ASMR