Stephen McPherson
Positions
- Postdoctoral Research Fellow, APCRC-Q
- Member, IHBI, QUT
Related websites and profiles
Qualifications
- PhD, Monash University, Melbourne, 2003
- MSc, Monash University, Melbourne, 1997
- BSC (Hons) Biochemistry, Monash University, Melbourne, 1993
Biography
In 1997, Dr McPherson completed a Masters Degree investigating the role of TGF-β related growth factors in prostate cancer from Monash University.
He went on to receive his PhD from Monash University in 2003 and subsequently took up a position at the Monash Institute of Medical Research at Monash University, where he investigated the role of hormonal regulation in controlling the development of benign and malignant prostate disease; leading to the study of the roles of steroid hormone receptors, particularly estrogen receptors, in prostate development and disease.
Dr McPherson joined the APCRC – Q to study the inter-relationship of AR and other nuclear hormone receptors with progesterone in prostate cancer and castrate-resistance.
Research interests
Changing expression of nuclear hormone receptors in prostate disease, prostatic response to the changing hormonal environment, aging, progression of prostate cancer, role of ERβas
Top publications
- McPherson SJ, Hussain S, Balanathan P, Hedwards SL, Niranjan B, Grant M, Chandrasiri UP, Toivanen R, Wang Y, Taylor RA, Risbridger GP. Estrogen receptor-beta activated apoptosis in benign hyperplasia and cancer of the prostate is androgen independent and TNFalpha mediated. Proc Natl Acad Sci U S A. 2010 107(7):3123-8. Epub 2010 Feb 1
- McPherson SJ, Ellem SJ, Risbridger GP. Estrogenic regulation of prostatic differentiation. Differentiation 2008 76(6):660-70
- Ricke WA, McPherson SJ, Bianco JJ, Cunha GR, Wang Y, Risbridger GP. Prostatic hormonal carcinogenesis is mediated by in situ estrogen production and estrogen receptor alpha-signaling. FASEB J 2008 22 (5):1512-20. Epub 2007 Nov 30
- McPherson SJ, Ellem SJ, Bianco JJ, Pedersen JS, Simpson ER, Almahbobi GA, Patchev V,Fritzemeier K-H, Risbridger GP. Essential role for ERb in stromal-epithelial regulation of prostatic hyperplasia. 2007 Endocrinology 148 (2):566-74
- McPherson SJ, Ellem SJ, Patchev V, Fritzemeier KH and Risbridger GP. The role of ER alpha and beta in the prostate: insights from genetic models and isoform-selective ligands. Ernst Schering Found Symp Proc. 2006. Tissue Specific Estrogen Action Novel Mechanisms, Novel Ligands Novel Therapies. Eds KS Korach, T Winterhamel. Springer-Verlag, Berlin.;1:131-47.
