Martin Sadowski
Positions
- Postdoctoral Research Fellow
- Institute of Pathology, University of Bern
Related websites and profiles
Qualifications
- PhD Biochemistry, Cell Biology, Biozentrum, University of Basel, Switzerland, 2002
- MBiol. (1st), Justus-Liebig-University of Giessen, Germany, 1998
Biography
In 2010, after 10 months of paternity leave, Dr. Sadowski joined the Australian Prostate Cancer Research Centre – Queensland. Over the past 18 years of lab work, Dr. Sadowski has acquired a strong expertise in a broad range of techniques of molecular biology, tissue culture, assay development, prostate cancer biology and drug discovery. His research projects investigate cancer cell proliferation and metabolism with a focus on hormone-regulated pathways of lipid metabolism, mitochondrial function and cell cycle progression. His recent work in drug discovery and prostate cancer biology contributed to 9 co-authored publications that describe the isolation and mechanism of action studies for novel natural compounds and synthetic agents, targeting topoisomerase, microtubule polymerisation, amino acid transport and fatty acid synthesis.
During his master’s degree and PhD studies, Dr. Sadowski worked on RNA binding proteins and their role in mRNA 3’-end processing. His work described the functional relationship of transcription termination and polyadenylation, leading to four highly cited publications in EMBO (2), JBC and Nucleic Acid Research and a postdoctoral fellowship from the German Research Foundation (DFG). His postdoctoral research in the Cancer Program at the Garvan Institute of Medical Research in Sydney and St. Vincent’s Institute of Medical Research in Melbourne investigated the role of protein phosphorylation and ubiquitination in cell cycle progression, demonstrating the existence of a sequence-specific mechanism with which E2 ubiquitin-conjugating enzymes select target lysines for ubiquitination. More importantly, it unveiled key amino acids in the catalytic core of the E2 enzyme that determine via compatibility with the target lysine sequence the mode of substrate ubiquitination: mono- or polyubiquitination, concluding in publications in MCB, JBC, Dev. Biol and Biochem J and three reviews..
Awards and grants
Awards
|
2015 |
Winner of the Presidential Poster Competition, 97th Annual Endocrinology Meeting, March 2015, San Diego, USA
|
|
2003-2004 |
Postdoctoral research fellowship, German Research Foundation |
Grants
|
2014-2017 |
Prostate Cancer Foundation of Australia, Movember Revolutionary Team Award |
Adaptive Response to Targeting the Androgen Axis – A Strategic Offensive on Resistance |
Nelson, Williams, Gunter, B Hollier, O'Leary, Lehman, Chopin, Hutmacher, Holst, Herington, Clements, Dinger |
|
|
2014-2015 |
Princess Alexandra Research Foundation: It's A Bloke's Thing Prostate Cancer Research Grant |
Targeting leptin in prostate cancer progression; linking metabolic dysfunction and castrate resistance. |
Nelson, Williams, Hollier, Gunter, Sadowski, Otvos, O’Leary |
|
|
2013-2017 |
Griffith University International |
Postgraduate Scholarship Phytochemical and biological investigations of cytotoxic compounds from Australian endemic plants |
Levrier (Supervisors: Davis, Nelson, Sadowski) |
Research interests
regulation of cell cycle progression, RNA processing, post-translational protein modification (phosphorylation and ubiquitination)
Top publications
-
Wang Q, Hardie RA, Hoy AJ, van Geldermalsen M, Gao D, Fazli L, Sadowski MC, Balaban S, Schreuder M, Nagarajah R, Wong JJ, Metierre C, Pinello N, Otte NJ, Lehman ML, Gleave M, Nelson CC, Bailey CG, Ritchie W, Rasko JE, Holst J. Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development. J Pathol, 2015 Jul;236(3):278-89.
-
Sadowski MC, Pouwer RH, Gunter JH, Lubik AA, Quinn RJ, Nelson CC. The fatty acid synthase inhibitor triclosan: repurposing an anti-microbial agent for targeting prostate cancer. Oncotarget. 2014 October 15;5(19):9362-81.
-
Sadowski M, Suryadinata R, Lai X, Heierhorst J, Sarcevic B. Molecular basis for lysine specificity in the yeast ubiquitin-conjugating enzyme Cdc34. Mol Cell Biol. 2010 May;30(10):2316-29. Epub 2010 Mar 1.
-
Sadowski M, Dichtl B, Hübner W, Keller W. Independent functions of yeast Pcf11p in pre-mRNA 3' end processing and in transcription termination. EMBO J. 2003 May 1;22(9):2167-77.
-
Dichtl B, Blank D, Sadowski M, Hübner W, Weiser S, Keller W. Yhh1p/Cft1p directly links poly(A) site recognition and RNA polymerase II transcription termination. EMBO J. 2002 Aug 1;21(15):4125-35.
