News

Patient-Derived Xenograft Models for Translational Prostate Cancer Research and Drug Development

Anja Rockstroh — 2024-04-28T00:00:00Z

This book chapter by Dr Philp et al aims to serve as a comprehensive resource for the preparation and adoption of PCa PDX models in the research laboratory and for their use as a valuable preclinical platform for translational research and therapeutic agent development.

Systematic review of antitumour efficacy and mechanism of metformin activity in prostate cancer models

Anja Rockstroh — 2022-09-30T00:00:00Z

Metformin, the first line pharmacotherapy for type 2 diabetes has demonstrated favourable effects in prostate cancer (PCa) across a range of studies evaluating PCa patient outcomes amongst metformin users. This review by Dr Gunter et al highlights the potential of metformin to be repurposed as an anticancer agent, warranting further investigation of metformin in the setting of PCa.

Movember 2023 Fundraising Sale

Anja Rockstroh — 2023-11-29T00:00:00Z

Great team effort for our Movember 2023 Fundraising sale - making a difference in the community, in research and in peoples’ lives!

PAH Giving Day 2023 Bake Sale

Anja Rockstroh — 2023-09-07T00:00:00Z

Our amazing team has raised $2702 from our bake sale to support the Princess Alexandra Hospital Giving Day 2023.

Gene expression based inference of cancer drug sensitivity

Anja Rockstroh — 2022-09-27T00:00:00Z

In this study, we introduce Precily, a predictive modeling approach to infer treatment response in cancers using gene expression data. We assessed the predictability of treatment outcomes and demonstrated the applicability of our approach on patient drug response data.

Neuropilin-1 is over-expressed in claudin-low breast cancer and promotes tumor progression through acquisition of stem cell characteristics and RAS/MAPK pathway activation

Anja Rockstroh — 2022-01-25T00:00:00Z

Our research by Dr Tang et al associates NRP1 expression with shorter relapse- and metastasis-free survival, which implicates NRP1 with the aggressive phenotype of claudin-low breast cancer and offers a novel targeted therapeutic approach to this poor prognosis subtype.

Leptin antagonism inhibits prostate cancer xenograft growth and progression

Anja Rockstroh — 2021-04-29T08:00:00Z

Our study by Dr Philp et al reveals the world-first preclinical evidence that demonstrates marked efficacy of targeted leptin-signalling blockade, using Allo-aca, a potent, specific, and safe LEPR peptide antagonist. This highlights LEPR blockade in combination with androgen axis inhibition as a promising new therapeutic strategy vital in advanced PCa treatment.

PA Giving Day PA Prostate Team Fundraising a Great Success

Lisa Philp — 2021-09-06T23:12:18Z

This PA Giving Day, the APCRC-Q raised over $13,800 thanks to the efforts of our wonderful PA Prostate team and the PA Research Foundation. Our Prostate team kicked off the day with a bake sale which was a huge success. Together the efforts of the PA Hospital community, the PA Giving Day collectively raised over $605,000 to fund patient support initiatives, medical research, staff education and specialist equipment at the PA Hospital Campus. A huge thanks to everyone for their support with donations on the day quadrupled, thanks to matching donors.

APCRC-Q Founder and Executive Director Professor Colleen Nelson Celebrated in Australia Day 2021 Honours

Lisa Philp — 2020-12-31T00:00:00Z

Professor Colleen Coyne Nelson was one of 117 Queenslanders recognised in the 2021 Australia Day Honours List for memorable contributions to the State and the nation, appointed a Member of the Order of Australia, for significant service to medical research, particularly prostate cancer, and to health organisations. We warmly congratulate Professor Nelson for this well-deserved achievement, which is testament to her unwavering dedication to translational prostate cancer research, to training, mentoring and nurturing hundreds of successful prostate cancer researchers, and to serving the community over the past three decades.

APCRC-Q Celebrates our 10 Year Anniversary

Lisa Philp — 2020-02-13T00:00:00Z

Together APCRC-Q researchers celebrated 10 years and reflected back on all the wonderful achievements our dedicated prostate cancer research centre has made over the past decade.

New prostate cancer therapeutics being developed by APCRC-Q researchers could also fight COVID-19

Lisa Philp — 2020-11-10T00:00:00Z

APCRC-Q researchers Dr Lisa Philp and Professor Colleen Nelson received media coverage for this exciting new work, with news articles published nationally in the Brisbane Times, Sydney Morning Herald and the Age. A story was also featured by QUT news.

APCRC-Q researchers provide commentary on recent cancer publications

Kathryn Arthy — 2020-02-10T00:00:00Z

Thirty eight different types of cancer, including prostate cancer, were represented in the international project. While APCRC-Q was not involved in the study, the Centre’s Associate Professors Elizabeth Williams and Jyotsna Batra provided independent expert commentary for a Brisbane Times news article and A/Prof Williams also featured on an ABC AM radio interview.

2019 Carla Patterson Award Winners

Kathryn Arthy — 2019-12-05T00:00:00Z

These awards recognise high-ranking journal articles that have the potential to significantly improve human health and make a difference to health and public good. All researchers at QUT’s Institute of Health and Biomedical Innovation are eligible for the publication awards that are held in memory of Prof Carla Patterson, who dedicated her life to public health research at QUT.

Dr Srinivasan was successful in the Early Career Researcher Award category, while Ms Martin won the Higher Degree Research Student category.

Movember Fundraising a Great Success

Kathryn Arthy — 2019-12-01T00:00:00Z

This Movember, APCRC-Q raised $5,445 thanks to the efforts of our wonderful team. We kicked off the month with a bake sale and backed that up with a pop-up nail salon. Our next event was a fabulous Beer Tasting evening in conjunction with Semi-Pro Brewery in South Brisbane. Meanwhile, our Movember Badminton Sunday session at South Bank TAFE has become an annual event and was as popular as ever this year.

Finally, we tried something a little different hosting the first ever Movember Recovery Breakfast. The turnout surpassed our expectations and it proved to be a great success.

A huge thank you to everyone who helped out arranging events, participated and donated time and money to this fantastic and important cause. Special mention to our top fundraisers: Nettie Ringuet who raised $1,505; Dr Jenni Gunter who, in addition to baking the mo-st adorable mo-biscuits, raised $1,330; and Dr Nathalie Bock who raised $1,000.

For more details check out APCRC-Q's Movember team page.

APCRC-Q researchers receive a Metro South Health Research Support Scheme Grant

Kathryn Arthy — 2019-11-22T00:00:00Z

The two-year grant will provide funding for their project entitled: ‘Do patients with high risk prostate cancer harbour viable gonorrhoeae diplococci in their prostate tissue?’

The announcement of the 2019 Metro South Health Board Chair Awards and the 2020 Research Support Scheme Grant recipients was held in the TRI Auditorium on Tuesday 19 November. The PA Foundation Research Awards were also announced at the annual event.

Almost 50 awards were presented on the evening totaling over $3 million in additional funding to support excellence in research that translates research discoveries into health and medical outcomes. The full list of recipients is available here.